Do you mean Poser Pro 2014? If so I'm using it fine on Windows 11 Education without issue. I didn't set anything special on the install either. I have turned off UAC but that should really only ask you if you want poser to run.

If you suspect it might be Adobe Air then you could try editing the Poser prefs file  (MAKE A BACKUP FIRST THOUGH!). This makes the libraries external as far as I remember. I had to do it or I get a blank library palate although Poser still launches.

I don't remember altering anything else. I hope this helps.