I’m using GNOME under Ubuntu 25.10. Overall, it doesn’t make much difference which of the major distributions you use. You’re on the safe side with any Debian-based distro (like Mint or Ubuntu). The WINE software, needed for Windows support, runs well on all major distributions.

However, I strongly recommend running all Windows apps inside a sandbox. That makes your system safer and easier to manage. I suggest using “Bottles” (a nod to “Wine”). It not only provides sandboxing but also makes configuration and module management easier. Bottles can be installed on nearly any distribution (Ubuntu, Mint, Fedora, etc.). It handles Wine installation automatically—which can take a little while, as it downloads and installs everything.

Here’s the link to Bottles (just for info what can be done and how it works): https://usebottles.com/

Hint: Make a description of all hardware you will use with linux. In case something won't work.

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