This came from Smith Micro. I have done the following and Poser now works fine.

KB3132372 which impacts Flash Management on Windows 10. Our Engineers are working to identify the root cause. Microsoft has acknowledged a known issues in this security update and they are aware of limited application crashes that occur after this security update is installed on Windows 10. Microsoft is researching this problem with Adobe and will post more information when the information becomes available. A work around is to uninstall the above update using Add and Remove Programs (Updates) The other option is to switch to the External Library that uses AIR if you do not wish to remove the problematic Update released by Microsoft earlier this week. To change to the External Library, go to C:UsersAppDataRoamingPoser Pro10 AppData may be hidden. Go your Control Panel, (Change from Categories to an Icon view on the right) select Folder Options and under the View Tab, select Show Hidden Files and Folders to allow you to view the AppData folder. Open the Poser.ini file using Notepad Locate the line LIBRARY_IS_AIR and change the 0 to a 1 Save and close. You can now launch and use Poser Pro with the External AIR Library. (NOTE: If you do not have AIR installed on your system, you will want to go to the Adobe Site and obtain the Latest AIR application from Adobe.)

John Csaky | Customer/Tech Support Smith Micro Software, Inc. | www.smithmicro.com