Two minor points.
If you are mapping to an external drive, and that drive is not connected, issues may occur.
If you are mapped to a drive that is completely full, issues will occur, this is especially true of the C: drive.

One additional point. Mapping your content to another drive is a typical thing to do. What many people don't realize is that you can map your temporary directories to a different drive. This is extremely effective if you map them to a high speed SSD. (High speed 64 GB and 128GB drives are getting to the pretty cheap price point.)

It is under preferences and there are two of them.