I guess it all depends on workflow. I find VSS almost ridiculously easy to use, but that sense of usability came after trying to frequently update 29 material zones, of which 15 are skin or skin-related zones.
However, in terms of lips, I have to use masks and for nipples, same thing. So those zones are more of a pain that helpful. I'd say 99% of Poser developers would disagree with me (based on what's in the marketplace) . I use masks a lot, and find it all very intuitive. So I guess it boils down to workflow.

Mine is complicated. Since I put makeup in a data .py file, I have to:

1. modify my make-up data file
2. make a small edit to my main script, just so that it needs to be saved
3. save both
4. matmatic compile
5. distribute mt5 files to VSS zones
6. run Ockham's Texture Filter script
7. synchronise

Yes, I don't mind doing all that... it is still a fair bit faster than the other way. So, since I'm fairly used to taking lots of steps to achieve my goals, using VSS is just another step.

Monterey/Mint21.x/Win10 - Blender3.x - PP11.3(cm) - Musescore3.6.2

Wir sind gewohnt, daß die Menschen verhöhnen was sie nicht verstehen
[it is clear that humans have contempt for that which they do not understand] 

Metaphor of Chooks