Hi, all files in a runtime are 'relative', and within any additional runtimes as well. It's references to files residing in outside folders that cause the problems. If I were you  I would do two things. First I would try running Poser in administrative mode. Also check your graphics drivers, most Poser problems stem from them. It's possible the files you're attempting to open have their preview set to openGL hardware support and this is where the troubles reside. One simple test is switch to SreeD for preview mode and make sure it's saved as the default. If things are more stable, then the graphics card's openGL isn't compatible with Poser. Try newer drivers and maybe switch to openGL sofware support under preview settings.

Regards...