I think it's that last point which made me hesitant about the details. I had the impression that there was a real Karen, who I was trying not to insult. The area between the eyes, and a little above, eyebrows and nose, looks pushed inward. I can't tell whether it's a lighting effect or the actual model. There's usually at least some slight step as the nose reaches the brow line, unless somebody has a big nose. As for the lips, try looking in a mirror, and compare how they part with the jaw closed, and as the teeth seperate. I don't know what morphs you have available, but the lower edge of the upper lip, and the upper edge of the lower lip, seems too straight. It's almost an animation problem. Think of it as a single frame in the middle of a movement. Is she breathing through her mouth, or starting to smile? If she's opening her mouth there can be a momentary stickiness -- surface tension? -- opposing the movement, and it isn't there when they're closing. And, I confess, it's the sort of slight lip-opening that I don't think I've ever managed to get convincing.